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【論文發表】Tandem reaction of heterocyclic ketene aminals with diazoesters: Synthesis of pyrimidopyrrolidone derivatives

2019年09月30日 16:20  點擊:[]

Tandem reaction of heterocyclic ketene aminals with diazoesters: Synthesis of pyrimidopyrrolidone derivatives

By: Kaixiu Luo, Weina Li, Jun Lin, Yi Jin

Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China

Tetrahedron Letters 60 (2019) 151136

doi.org/10.1016/j.tetlet.2019.151136

Publication Date (Web): September 10, 2019

Document Type: Article

Abstract

A tandem reaction of heterocyclic ketene aminals (HKAs) with diazoesters in the presence of a Cu catalyst is demonstrated for the efficient synthesis of pyrimidopyrrolidone derivatives. The reaction shows a broad substrate scope and excellent functional group tolerance. Our method provides rapid access to diverse pyrimidopyrrolidones in moderate to excellent yields under mild reaction conditions.

全文鏈接:

https://www.sciencedirect.com/science/article/pii/S0040403919309049


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